Secretory vesicles deliver Cdc42p to sites of polarized growth in S. cerevisiaeArticle
he activation and localization of the Rho-family GTPase Cdc42p at one pole of a cell is necessary for maintaining an axis of polarized growth in many animal and fungal cells. How the asymmetric distribution of this key regulator of polarized morphogenesis is maintained is not fully understood, though divergent models have emerged from a congruence of multiple studies, including one that posits a role for polarized secretion. Here we show with S. cerevisiae that Cdc42p associates with secretory vesicles in vivo.
polarized cell growth, exocytosis, Cdc42, Rho GTPase
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Kozminski, Keith, and Shubha Dighe. "Secretory vesicles deliver Cdc42p to sites of polarized growth in S. cerevisiae." PLoS One 9.6 (2014): e99494. Available: ["http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099494"].
Public Library of Science
National Science Foundation, University of Virginia
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